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Lexapro is prescribed for major depression—a persistently low mood that interferes with daily functioning. To be considered major, depression must occur nearly every day for at least two weeks, and must include at least five of the following symptoms: low mood, loss of interest in usual activities, significant change in weight or appetite, change in sleep patterns, agitation or lethargy, fatigue, feelings of guilt or worthlessness, slowed thinking or lack of concentration, and thoughts of suicide.

Lexapro is also prescribed for generalized anxiety disorder, a condition marked by excessive worry and anxiety that is hard to control and interferes with daily life. To be diagnosed with this disorder, your symptoms must have lasted at least 6 months and you must have at least three of the following: restlessness, fatigue, poor concentration, irritability, muscle tension, and sleep disturbances.

Lexapro works by boosting levels of serotonin, one of the chief chemical messengers in the brain. The drug is a close chemical cousin of the antidepressant medication citalopram. Other antidepressants that work by raising serotonin levels include fluoxetine, paroxetine, and sertraline.

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GENERIC NAME: escitalopram
BRAND NAME: Lexapro

DRUG CLASS AND MECHANISM: Escitalopram is an oral drug that is used for treating depression and generalized anxiety disorder. Chemically, escitalopram is similar to citalopram (Celexa). Both are in the class of drugs called selective serotonin reuptake inhibitors (SSRIs), a class that also includes fluoxetine (Prozac), paroxetine (Paxil) and sertraline (Zoloft). SSRIs work by affecting neurotransmitters in the brain, the chemical messengers that nerves use to communicate with one another. Neurotransmitters are made and released by nerves and then travel to other nearby nerves where they attach to receptors on the nerves. Some neurotransmitters that are released do not bind to receptors and are taken up by the nerves that produced them. This is referred to as "reuptake." Many experts believe that an imbalance of neurotransmitters is the cause of depression. Escitalopram prevents the reuptake of one neurotransmitter, serotonin, by nerves, an action which results in more serotonin in the brain to attach to receptors. The FDA approved escitalopram in August 2002.